Lipocalin 2 (LCN2) Expression in Hepatic Malfunction and Therapy
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منابع مشابه
Lipocalin 2 (LCN2) Expression in Hepatic Malfunction and Therapy
Lipocalin 2 (LCN2) is a secreted protein that belongs to the Lipocalins, a group of transporters of small lipophilic molecules such as steroids, lipopolysaccharides, iron, and fatty acids in circulation. Two decades after its discovery and after a high variety of published findings, LCN2's altered expression has been assigned to critical roles in several pathological organ conditions, including...
متن کاملLipocalin 2 (LCN2) is a promising target for cholangiocarcinoma treatment and bile LCN2 level is a potential cholangiocarcinoma diagnostic marker
Cholangiocarcinoma (CCA) is a devastating disease due to resistance to traditional chemotherapies and radiotherapies. New therapeutic strategies against CCA are urgently needed. This study investigated the role of lipocalin-2 (LCN2) in human cholangiocarcinoma as a potential therapeutic target and diagnostic marker. So far, the role of LCN2 in cancer is still controversial and studies regarding...
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319 Received September 28, 2010; revision accepted for publication November 21, 2010. doi: 10.1620/tjem.222.319 Correspondence: Jin-Wook Kim, Department of Internal Medicine, Seoul National University Bundang Hospital, Gumi-dong 300, Seongnam, Kyonggi-Do 463-802, South Korea. e-mail: [email protected] Increased Urinary Lipocalin-2 Reflects Matrix Metalloproteinase-9 Activity in Chronic Hepatitis ...
متن کاملInduction of Heme Oxygenase -1 By Lipocalin 2 Mediated By Nf-Kb Transcription Factor
Purpose: Effect of lipocalin 2 on the expression of heme oxygenase I , II and NF-kB transcription factor was the purpose of this survey. Materials and Methods: Lcn2 was cloned to pcDNA3.1 plasmid by using genetic engineering method. The recombinant vector was transfected to CHO and HEK293T to establish stable cell expressing lipocalin 2. The presence of lipocalin 2 gene in these cells was confi...
متن کاملHigh Frequency Electromagnetic Field Induces Lipocalin 2 Expression in Mouse Liver
Objective(s) Neutrophil gelatinase-associated lipocalin (NGAL/Lcn2), comprise a group of small extracellular proteins with a common P-sheet-dominated 3-dimensional structure. In the past, it was assumed that the predominant role of lipocalin was acting as transport proteins. Recently it has been found that oxidative stress induces Lcn2 expression. It has been also proved that electromagnetic f...
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ژورنال
عنوان ژورنال: Frontiers in Physiology
سال: 2016
ISSN: 1664-042X
DOI: 10.3389/fphys.2016.00430